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Santana endorses PRS Guitars. He uses a Santana II model guitar using PRS Santana III pickups with covers and a tremolo, with .09-.42 gauge D'Addario strings.
The PRS Santana guitar neck, similar to those found on classical guitars, is thicker than most electric guitar necks. PRS Santana guitar necks are constructed out of a single solid piece of Brazilian Rosewood, rather than the more traditional mahogany/rosewood combination. The Brazilian Rosewood helps create the smooth, singing, glass-like tone commonly heard in his work.
Carlos Santana also uses a classical guitar, the Alvarez Yairi CY127CE with Alvarez tension nylon strings. For a classical sound Carlos plays with the pick not far from the guitar bridge.
For the distinctive Santana electric guitar sound, Carlos doesn't need too many effects pedals. His PRS guitar is connected to a Mu-Tron wah wah pedal and a T-Rex Replica delay pedal, then through a customized Jim Dunlop amp switcher which in turn is connected to the different amps or cabinets.
Previous setups include an Ibanez Tube Screamer right after the guitar.
Carlos combines a Mesa/Boogie Mark I head running through a Boogie cabinet with Altec 417-8A speakers, and a Dumble Overdrive Reverb and/or a Dumble Overdrive Special running through a Brown or Marshall 4x12 cabinet with Celestion G12M speakers, depending on the desired sound. Shure KSM-32 microphones are used to pick up the sound, going to the PA. Additionally, a Fender Cyber-Twin Amp is mostly used at home.http://en.wikipedia.org/wiki/Carlos_Santana#Equipment